Publications

Explore a selection of our publications to date below.

TitleJournal/ConferenceYearjournal_hfiltertest_hfilterdate_hfiltertumor_type_hfilterbiomarker_hfilterpublication_year_hfilter
Economic Burden of Checkpoint Inhibitor Immunotherapy for the Treatment of Non-Small Cell Lung Cancer in US Clinical PracticeClinical Therapeutics2020clinical-therapeuticsnon-small-cell-lung-cancerimmune-profile2020
Proliferative potential and response to nivolumab in clear cell renal cell carcinoma patientsOncoImmunology2020oncoimmunologymsi pd-l1-ihc rnaseq tmbrenal-cell-carcinomacell-proliferation2020
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneityOncoImmunology2020oncoimmunologymsi pd-l1-ihc rnaseq tmbsolid-tumorsimmune-profile2020
Distinct pathways of DC-induced CD8+ T cell differentiation revealed by single-cell mRNA sequencing analysisAACR Annual Meeting 20202020aacr-annual-meeting-2020rnaseqimmune-cellsimmune-profile2020
Single-cell mRNA sequencing analysis of the synergistic impact of double-stranded RNA (dsRNA) and IFNa on human monocyte-derived macrophagesAACR Annual Meeting 20202020aacr-annual-meeting-2020rnaseqimmune-cellsimmune-profile2020
Molecular characterization of advanced muscle invasive bladder cancer (MIBC): Comparison of low-input targeted RNA sequencing (RNAseq) strategies2020 Genitourinary Cancers Symposium20202020-genitourinary-cancers-symposiumrnaseqbladder-cancercomparator-study2020
Inflammation and cell proliferation signatures: Implications for response to immune checkpoint inhibition therapies2020 ASCO-SITC Clinical Immuno-Oncology Symposium20202020-asco-sitc-clinical-immuno-oncology-symposiumrnaseqsolid-tumorscell-proliferation inflammation tumor-immunogenic-signature2020
Tumor inflammatory signature as a biomarker of response to immunotherapy in lung cancer2020 ASCO-SITC Clinical Immuno-Oncology Symposium20202020-asco-sitc-clinical-immuno-oncology-symposiumrnaseqlung-cancerinflammation tumor-immunogenic-signature2020
TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for CancerFrontiers in Immunology2020frontiers-in-immunologytcrbmelanomactla-4 tcr%ce%b22020
Development and analytical validation of a next-generation sequencing based microsatellite instability (MSI) assayOncotarget2019oncotargetmsisolid-tumorsanalytical-validation2019
Unique Tumor Immune Microenvironments Of Potentially PD-L1/TGF-β Trap Responsive TumorsSITC's 34th Annual Meeting (2019)2019sitcs-34th-annual-meeting-2019msi pd-l1-ihc rnaseq tmbsolid-tumorsbispecifics tme2019
CT Antigens are Frequently Expressed in Non-Inflamed TumorsSITC's 34th Annual Meeting (2019)2019sitcs-34th-annual-meeting-2019msi pd-l1-ihc rnaseq tmbsolid-tumorsct-antgiens tme2019
Haplotype Analysis of the T-Cell Receptor Beta (TCRB) Locus by Long-amplicon TCRB Repertoire SequencingJournal of Immunotherapy and Precision Oncology2019journal-of-immunotherapy-and-precision-oncologytcrbperipheral-blood-leukocyteshaplotype-analysis tcr%ce%b22019
Body Mass Index Influences the Salutary Effects of Metformin on Survival After Lobectomy for Stage I NSCLCJournal of Thoracic Oncology2019journal-of-thoracic-oncologyrnaseqsolid-tumorsbmi immune-profile metformin2019
Oncologist uptake of comprehensive genomic profile guided targeted therapyOncotarget2019oncotargetocpsolid-tumorsclinical-decision-making clinical-utility2019
Cell proliferation as a biomarker for response to immune checkpoint inhibitors in PD-L1 negative renal cell carcinomaASCO-SITC Clinical Immuno-Oncology Symposium - 20192019asco-sitc-clinical-immuno-oncology-symposium-2019msi pd-l1-ihc rnaseq tmbrenal-cell-carcinomacell-proliferation patient-response tumor-inflammation2019
Cell proliferation as a biomarker for response to immune checkpoint inhibitors in highly inflamed renal cell carcinoma (RCC)ASCO-SITC Clinical Immuno-Oncology Symposium - 20192019asco-sitc-clinical-immuno-oncology-symposium-2019msi pd-l1-ihc rnaseq tmbrenal-cell-carcinomacell-proliferation patient-response tumor-inflammation2019
Tumor Mutational Burden (TMB): Assessment of Inter-and Intra-tumor heterogeneityASCO-SITC Clinical Immuno-Oncology Symposium - 20192019asco-sitc-clinical-immuno-oncology-symposium-2019tmbsolid-tumorscomparator-study specimen-characteristics validation2019
RNA-sequencing reveals immunotherapy targets in gynecological cancerASCO-SITC Clinical Immuno-Oncology Symposium - 20192019asco-sitc-clinical-immuno-oncology-symposium-2019msi pd-l1-ihc rnaseq tmbgynocological-cancersimmune-profile immune-suppression2019
Proliferative potential and resistance to immune checkpoint blockade in lung cancer patientsJournal for ImmunoTherapy of Cancer2019journal-for-immunotherapy-of-cancermsi pd-l1-ihc rnaseq tmbnon-small-cell-lung-cancercell-proliferation patient-survival2019
Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitorsJournal for ImmunoTherapy of Cancer2019journal-for-immunotherapy-of-cancerpd-l1-ihc rnaseqsolid-tumorscomparator-study patient-response pd-l12019
Treatment recommendations to cancer patients in the context of FDA guidance for next generation sequencingBMC Medical Informatics and Decision Making2019bmc-medical-informatics-and-decision-makingocpsolid-tumorsclinical-decision-making clinical-utility2019
RNA-Expression Profiling Reveals Immunotherapy Targets in SarcomaJournal of Sarcoma Research2018journal-of-sarcoma-researchmsi pd-l1-ihc rnaseq tmbsarcomaimmune-profile myeloid-suppression2018
Identification of targets for prostate cancer immunotherapyThe Prostate2018the-prostatemsi pd-l1-ihc rnaseq tmbprostate-cancerimmune-profile2018
Tumor mutational burden (TMB) ring study: Comparison of multiple targeted next-generation sequencing (NGS) platformsASCO-SITC Clinical Immuno-Oncology Symposium - 20182018asco-sitc-clinical-immuno-oncology-symposium-2018tmbsolid-tumorscomparator-study tmb2018
Identifying major immune subsets of GI tumors for clinical purposesSITC's 33rd Annual Meeting (2018)2018sitcs-33rd-annual-meeting-2018msi pd-l1-ihc rnaseq tmbgi-tumorsimmune-profile2018
Development of a next-generation sequencing-based microsatellite instability assay (MSI NGS) for solid tumor testingSITC's 33rd Annual Meeting (2018)2018sitcs-33rd-annual-meeting-2018msisolid-tumorsanalytical-validation2018
Cell Proliferation Defines an Additional Mechanism of Immune Escape in Non-Small Cell Lung CancerASCO-SITC Clinical Immuno-Oncology Symposium - 20182018asco-sitc-clinical-immuno-oncology-symposium-2018pd-l1-ihcnon-small-cell-lung-cancercell-proliferation patient-survival2018
Combination immunotherapy selection for non-PD-1 axis driven tumors2018 ASCO Annual Meeting20182018-asco-annual-meetingrnaseqsolid-tumorsimmune-profile2018
Combination immunotherapy selection for PD-1 axis driven tumors2018 ASCO Annual Meeting20182018-asco-annual-meetingrnaseqsolid-tumorsimmune-profile2018
PD-L2 amplification and durable disease stabilization in patient with urothelial carcinoma receiving pembrolizumabOncoImmunology2018oncoimmunologymsi pd-l1-ihc rnaseq tmburothelial-carcinomaimmune-profile patient-response pd-l22018
Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burdenJournal for ImmunoTherapy of Cancer2018journal-for-immunotherapy-of-cancermsi pd-l1-ihc rnaseq tmbmelanomapatient-survival tumor-inflammation2018
Chemokine expression signatures in infiltrated vs non-infiltrated tumorsAACR Annual Meeting 20182018aacr-annual-meeting-2018msi pd-l1-ihc rnaseq tmbsolid-tumorschemokines infiltrated-tumors tumor-infiltrating-lymphocytes2018
PD-L1 driven excluded phenotype in melanomaAACR Annual Meeting 20182018aacr-annual-meeting-2018msi pd-l1-ihc rnaseq tmbmelanomacd8 excluded-phenotype2018
Predicting Response: PD-L1 Biomarker Testing by IHC and RNA-seqAACR Annual Meeting 20182018aacr-annual-meeting-2018msi pd-l1-ihc rnaseq tmbsolid-tumorspatient-response pd-l12018
Immune Deserts: Low CD8 Gene Expression Correlates with Non-response to Checkpoint InhibitionASCO-SITC Clinical Immuno-Oncology Symposium - 20182018asco-sitc-clinical-immuno-oncology-symposium-2018msi pd-l1-ihc rnaseq tmbsolid-tumorscd8 patient-response2018
Comprehensive Immune and Mutational Profile of MelanomaASCO-SITC Clinical Immuno-Oncology Symposium - 20182018asco-sitc-clinical-immuno-oncology-symposium-2018oamelanomaimmune-profile mutational-profile2018
CTLA-4 Overexpression Does Not Confer Response to Ipilimumab in MelanomaASCO-SITC Clinical Immuno-Oncology Symposium - 20182018asco-sitc-clinical-immuno-oncology-symposium-2018oamelanomactla4 patient-response2018
Lung Cancer Mutational Profile Correlates with Immune ProfileASCO-SITC Clinical Immuno-Oncology Symposium - 20182018asco-sitc-clinical-immuno-oncology-symposium-2018msi pd-l1-ihc rnaseq tmblung-cancerimmune-profile mutational-profile2018
Overexpression of Immunotherapeutic Targets in the Immune Desert PhenotypeSITC's 32nd Annual Meeting (2017)2017sitcs-32nd-annual-meeting-2017msi pd-l1-ihc rnaseq tmbsolid-tumorsimmune-desert immune-profile2017
Comprehensive Characterization of Solid Tumor Immune Profiles for Precision Immunotherapy Using Immune Report Card℠SITC's 32nd Annual Meeting (2017)2017sitcs-32nd-annual-meeting-2017msi pd-l1-ihc rnaseq tmbsolid-tumorsimmune-profile2017
The Immune-Excluded Phenotype Beyond Colorectal CancerSITC's 32nd Annual Meeting (2017)2017sitcs-32nd-annual-meeting-2017msi pd-l1-ihc rnaseq tmbsolid-tumorscd8 excluded-phenotype2017
Secondary Immunotherapeutic Targets In Inflamed TumorsSITC's 32nd Annual Meeting (2017)2017sitcs-32nd-annual-meeting-2017msi pd-l1-ihc rnaseq tmbsolid-tumorsimmune-profile tumor-inflammation2017
Analytical Validation of a Next-Generation Sequencing Assay to Monitor Immune Responses in Solid TumorsThe Journal of Molecular Diagnostics2017the-journal-of-molecular-diagnosticsmsi pd-l1-ihc rnaseq tmbsolid-tumorsanalytical-validation2017
Algorithmic Prediction of Response to Checkpoint Inhibitors2017 ASCO Annual Meeting20172017-asco-annual-meetingrnaseqsolid-tumorspatient-response predicitve-algorithm2017
The Inflamed Phenotype in PD-L1 Negative Melanoma and Response to Checkpoint InhibitorsImmunology 20172017immunology-2017msi pd-l1-ihc rnaseq tmbmelanomapatient-response tumor-inflammation2017
The Inflamed Phenotype in PD-L1 Negative NSCLC and Response to Checkpoint InhibitorsImmunology 20172017immunology-2017msi pd-l1-ihc rnaseq tmbnon-small-cell-lung-cancerpatient-response tumor-inflammation2017
Technical variability in NGS immune gene expression and mutation profiling has a nominal effect on tumor classificationAACR Annual Meeting 20172017aacr-annual-meeting-2017msi pd-l1-ihc rnaseq tmbsolid-tumorsspecimen-characteristics validation2017
NGS reveals specimen characteristics have minimal impact on immune gene expression signatureAACR Annual Meeting 20172017aacr-annual-meeting-2017rnaseqspecimen-characteristics validation2017
Tumor microenvironment heterogeneity is not identified across multiple histologically similar tumors from the same patientAACR Annual Meeting 20172017aacr-annual-meeting-2017msi pd-l1-ihc rnaseq tmbsolid-tumorsspecimen-characteristics validation2017
Analytical Validation of an Immune Response Assay for Classifying Solid Tumors2017 ASCO Annual Meeting20172017-asco-annual-meetingmsi pd-l1-ihc rnaseq tmbanalytical-validation2017
Robust detection of immune transcripts in FFPE samples using targeted RNA sequencingOncotarget2016oncotargetmsi pd-l1-ihc rnaseq tmbsolid-tumorscomparator-study specimen-characteristics validation2016
An Algorithmic Approach to Cancer Immune ProfilingSITC's 31st Annual Meeting (2016)2016sitcs-31st-annual-meeting-2016msi pd-l1-ihc rnaseq tmbsolid-tumorspatient-response predicitve-algorithm2016
Validation of a Custom RNA-Seq Approach to Cancer Immune ProfilingSITC's 31st Annual Meeting (2016)2016sitcs-31st-annual-meeting-2016msi pd-l1-ihc rnaseq tmbsolid-tumorscomparator-study specimen-characteristics validation2016